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Article

Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy

24 Oct 2014

Abstract excerpt

BACKGROUND: Cetuximab, an anti-EGFR monoclonal antibody, is used to treat several cancers. However, many patients who initially respond to cetuximab acquire resistance. To examine mechanisms of acquired resistance, we developed a series of cetuximab-resistant (Ctx(R)) clones derived from the cetuximab sensitive (CtxS) non-small cell lung cancer (NSCLC) cell line H226. Previous studies characterizing this model...

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PMID: 25344208
DOI: 10.1186/1476-4598-13-242

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