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Article

LAM cells biology and lymphangioleiomyomatosis.

Folia histochemica et cytobiologica - 1 Jan 2013

Grzegorek Irmina, Drozdz Katarzyna, Podhorska-Okolow Marzenna, Szuba Andrzej, Dziegiel Piotr

Abstract excerpt

Progressive lung tissue destruction in lymphangioleiomyomatosis (LAM) occurs as a result of excessive proliferation of LAM cells caused by a mutation in one of the tuberous sclerosis complex suppressor genes, TSC1 or TSC2. These cells show constitutive activation of the mammalian target of rapamycin (mTOR) pathway and many of the mTOR-related kinases such as Akt, Erk, S6K1 and S6. Phenotype of LAM cells differs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23690211
DOI: 10.5603/FHC.2013.001

Genes

TSC2
TSC1

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