Article
Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Hedrick P W, Whittam T S, Parham P
Abstract excerpt
The amino acid heterozygosities per site for HLA-A and -B loci are determined to be extremely high by combining population serotypic frequencies with amino acid sequences. For the 54 amino acid sites thought to have functional importance, the average heterozygosity per site is 0.301. Sixteen positions have heterozygosities greater than 0.5 at one or both loci and the frequencies of amino acids at a given position...
Topics
- Alleles
- Amino Acid Sequence
- Gene Frequency
- Genetics, Population
- HLA-A Antigens
- HLA-B Antigens
- Heterozygote
- Humans
- Protein Conformation
- Statistics as Topic