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Article

A multilevel model to address batch effects in copy number estimation using SNP arrays.

Biostatistics (Oxford, England) - 1 Jan 2011

Scharpf Robert B, Ruczinski Ingo, Carvalho Benilton, Doan Betty, Chakravarti Aravinda, Irizarry Rafael A

Abstract excerpt

Submicroscopic changes in chromosomal DNA copy number dosage are common and have been implicated in many heritable diseases and cancers. Recent high-throughput technologies have a resolution that permits the detection of segmental changes in DNA copy number that span thousands of base pairs in the genome. Genomewide association studies (GWAS) may simultaneously screen for copy number phenotype and single...

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Identifiers

PMID: 20625178
DOI: 10.1093/biostatistics/kxq043
PMCID: PMC3006124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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