Article
Cooperative formation of native-like tertiary contacts in the ensemble of unfolded states of a four-helix protein.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010
Bruun Susanne W, Iesmantavicius Vytautas, Danielsson Jens, Poulsen Flemming M
Abstract excerpt
In studies of the ensembles of unfolded structures of a four-helix bundle protein, we have detected the presence of potential precursors of native tertiary structures. These observations were based on the perturbation of NMR chemical shifts of the protein backbone atoms by single site mutations. Some mutations change the chemical shifts of residues remote from the site of mutation indicating the presence of an...
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