Article
Tamm-Horsfall protein gene is associated with distal tubular dysfunction in patients with type 1 diabetes.
Scandinavian journal of urology and nephrology - 1 Dec 2010
Möllsten Anna, Torffvit Ole
Abstract excerpt
OBJECTIVE: The first changes in the diabetic kidney are glycogen deposits in the epithelial cells of the thick ascending limb of Henle, which leads to decreased production of Tamm-Horsfall protein (THP). The production of THP is also influenced by nitric oxide (NO). The aims of this study were to investigate whether low excretion of THP, a sign of distal tubular dysfunction, in patients with type 1 diabetes was...
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