Article
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
Invasion & metastasis - 1 Jan 1991
Young M R, Okada F, Tada M, Hosokawa M, Kobayashi H
Abstract excerpt
Secretion of prostaglandin E2 (PGE2) by cloned variants of QR fibrosarcoma or of Lewis lung carcinoma (LLC) did not correspond with their in vivo aggressive behavior. However, aggressiveness may be influenced by tumor responsiveness to PGE2. Each of the metastatic LLC or progressor QRpP variants was more motile in an in vitro migration model than were either the nonmetastatic LLC or regressor QR variants. One of...
Topics
- Animals
- Cell Line
- Cell Movement
- Clone Cells
- Dinoprostone
- Fibrosarcoma
- Genetic Variation
- Indomethacin
- Lung Neoplasms
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis