A MEQ-Deleted Marek's Disease Virus Cloned as a Bacterial Artificial Chromosome Is a Highly Efficacious Vaccine

Abstract excerpt

The Marek's disease virus (MDV) induces T-cell tumors in susceptible chickens. Of the 80 to 100 known MDV genes, only the MDV MEQ gene was shown to have transforming properties. Further evidence that MEQ is probably the principal oncogene in MDV came when researchers used overlapping cosmid clones of MDV and demonstrated that deleting MEQ resulted in a highly protective Marek's disease (MD) vaccine. We deleted...

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