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Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function

24 May 2018

Abstract excerpt

Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC) clones of Marek’s disease virus genome have identified major genes that are associated with pathogenicity. Recent advances in CRISPR/Cas9-based...

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PMID: 29794970
DOI: 10.3390/v10060279

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