Article
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.
Biochemical and biophysical research communications - 30 Jul 2010
Lopez Giselle Y, Reitman Zachary J, Solomon David, Waldman Todd, Bigner Darell D, McLendon Roger E, Rosenberg Steven A, Samuels Yardena, Yan Hai
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). IDH1/2 were recently identified as mutated in a large percentage of progressive gliomas. These mutations occur at IDH1(R132) or the homologous IDH2(R172). Melanomas share some genetic features with...
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