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Article

A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients.

European journal of internal medicine - 1 Aug 2010

Beretta Lorenzo, Santaniello Alessandro, Mayo Michael, Cappiello Francesca, Marchini Maurizio, Scorza Raffaella

Abstract excerpt

BACKGROUND: The genetic background may predispose systemic sclerosis (SSc) patients to the development of digital ulcers (DUs). METHODS: Twenty-two functional cytokine single nucleotide polymorphisms (SNPs) and 3 HLA class I and II antigens were typed at the genomic level by polymerase chain reaction in 200 Italian SSc patients. Associations with DUs were sought by parametric models and with the Multifactor...

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PMID: 20603050
DOI: 10.1016/j.ejim.2010.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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