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An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance.

Theoretical population biology - 1 Sept 2010

Schneider Kristan A, Kim Yuseob

Abstract excerpt

We analytically study a deterministic model for the spread of drug resistance among human malaria parasites. The model incorporates all major characteristics of the complex malaria transmission cycle and accounts for the fact that only a fraction alpha of infected hosts receive drug treatment. Furthermore, the model incorporates that hosts can be co-infected. The number m of parasites co-infecting a host is...

Topics

Alleles
Animals
Anopheles
Antimalarials
Drug Resistance
Genetic Variation
Humans
Insect Vectors
Malaria, Falciparum
Models, Genetic
Plasmodium falciparum
Selection, Genetic

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Identifiers

PMID: 20600206
DOI: 10.1016/j.tpb.2010.06.005
PMCID: PMC2916054

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