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Article

Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice.

Gastroenterology - 1 Oct 2010

Zizer Eugen, Beilke Sven, Bäuerle Tobias, Schilling Kerstin, Möhnle Ursula, Adler Guido, Fischer Klaus-Dieter, Wagner Martin

Abstract excerpt

BACKGROUND & AIMS: Lsc/p115 originally was described as hematopoietic Ras homologous protein guanine exchange factor (Rho-GEF) regulating leukocyte migration, adhesion, and marginal zone B-cell homeostasis. Here we investigate the expression pattern of lsc/p115 in the gastrointestinal tract and the consequences of lsc/p115 deficiency in lsc/p115-knockout mice. METHODS: The phenotype of lsc/p115-deficient mice was...

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Identifiers

PMID: 20600037
DOI: 10.1053/j.gastro.2010.06.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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