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Article

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

Biochemistry - 25 Jun 1991

Kronbach T, Kemper B, Johnson E F

Abstract excerpt

Cytochrome P450IIC5 is a hepatic progesterone 21-hydroxylase while the 95% identical P450IIC4 has a greater than 10-fold higher Km for progesterone 21-hydroxylation and the 74% identical P450IIC1 does not hydroxylate progesterone at detectable rates. Previous work demonstrated that the apparent Km of P450IIC4 for progesterone 21-hydroxylation can be markedly improved by replacing a valine at position 113 with an...

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PMID: 2059619
DOI: 10.1021/bi00239a003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.PMID 2059619Read ↗

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