Article
Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5.
The Journal of biological chemistry - 25 Aug 1990
Pendurthi U R, Lamb J G, Nguyen N, Johnson E F, Tukey R H
Abstract excerpt
Rabbits exhibit two heritable phenotypes, 21L and 21H, with the latter displaying roughly 10-fold higher liver microsomal progesterone 21-hydroxylase activity. The higher activity of the 21H animals reflects the elevated expression of cytochrome P-450 1 (P450IIC5). Breeding studies indicate that...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Cytochrome P-450 Enzyme System
- Cytochrome P450 Family 2
- DNA
- Female
- Gene Expression Regulation, Enzymologic
- Genes
- Genetic Variation
- Liver
- Male
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymerase Chain Reaction