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Article

Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.

Cancer research - 15 Jul 2010

Bellodi Cristian, Krasnykh Olya, Haynes Nikesha, Theodoropoulou Marily, Peng Guang, Montanaro Lorenzo, Ruggero Davide

Abstract excerpt

Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysfunction and increased cancer susceptibility in the human syndrome, X-linked dyskeratosis congenita (X-DC). In a mouse model for X-DC, impairments in DKC1 function affected the translation of specific mRNAs harboring internal ribosomal entry site (IRES)...

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Topics

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Share to Cell Cycle Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Genes, Tumor Suppressor

Share to Mice, Transgenic

Share to Nuclear Proteins

Share to Pituitary Neoplasms

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20587522
DOI: 10.1158/0008-5472.CAN-09-4730
PMCID: PMC2913864

Genes

DKC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.PMID 20587522Read ↗

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