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Article

Anomalous electrophoretic migration of newly synthesized ribosomal RNAs and their precursors from cells with DKC1 mutations.

FEBS letters - 17 Sept 2009

Gu Bai-Wei, Zhao Chunjun, Fan Jian-Meng, Dai Qing, Bessler Monica, Mason Philip J

Abstract excerpt

Mutations in the X-linked gene, DKC1, encoding dyskerin, cause dyskeratosis congenita by leading to decreased telomerase activity and causing short telomeres. Dyskerin is also a pseudouridine synthase that modifies nascent ribosomal and other RNAs and it is not known if this function is affected by the mutations. Here we show that newly synthesized ribosomal RNA, extracted from human and mouse cells with...

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Identifiers

PMID: 19729012
DOI: 10.1016/j.febslet.2009.08.038
PMCID: PMC2745346

Genes

DKC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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