Hunting for robust gene signature from cancer profiling data: sources of variability, different interpretations, and recent methodological developments.

Abstract excerpt

Gene microarray is a powerful platform to investigate the expression patterns of thousands of genes simultaneously. One central objective of such analysis is to select sets of genes (i.e., gene signatures) which correlate with clinical characteristics, such as disease subtype diagnosis, response to drug treatment and prognosis. However, previous studies have found that mRNA signatures are highly unstable and...

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