Article
Prevalence of HIV-1 polymerase gene mutations in pre-treated patients in Thailand.
The Southeast Asian journal of tropical medicine and public health - 1 Mar 2002
Chantratita Wasun, Jenwitheesuk Ekachai, Watitpun Chotip, Pongthanapisith Viroj, Vibhagool Asda, Leechawengwong Manoon, Sookpranee Mondej, Apairatana Anantasak
Abstract excerpt
To determine the prevalence of drug resistance-conferring mutations in human immunodeficiency virus type 1 (HIV-1), 83 HIV-1 infected Thai patients who had been treated with any antiretroviral drug were studied. HIV-1 RNA was reverse transcribed and amplified by RT-PCR. The direct sequencing of HIV-1 reverse transcriptase (RT) and protease was then performed. Changes in nucleotide and amino acid sequences were...
Topics
- DNA-Directed RNA Polymerases
- Drug Resistance, Viral
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Mutation
- Phylogeny