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Article

MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures.

Journal of cellular physiology - 1 Sept 2010

Roman-Blas J, Dion A S, Seghatoleslami M R, Giunta K, Oca P, Jimenez S A, Williams C J

Abstract excerpt

Mutations in cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). We studied the effects of over-expression of wild type and mutant COMP on early stages of chondrogenesis in chicken limb bud micromass cultures. Cells were transduced with RCAS virus harboring wild type or mutant (C328R, PSACH; T585R, MED) COMP cDNAs and cultured for 3, 4, and 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20578249
DOI: 10.1002/jcp.22185

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MED and PSACH COMP mutations affect chondrogenesis in chicken limb bud micromass cultures.PMID 20578249Read ↗

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