Article
Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta.
Frontiers in endocrinology - 1 Jan 2022
Forte-Gomez Helena Fabiana, Gioia Roberta, Tonelli Francesca, Kobbe Birgit, Koch Peter, Bloch Wilhelm, Paulsson Mats, Zaucke Frank, Forlino Antonella, Wagener Raimund
Abstract excerpt
COMP (Cartilage Oligomeric Matrix Protein), also named thrombospondin-5, is a member of the thrombospondin family of extracellular matrix proteins. It is of clinical relevance, as in humans mutations in COMP lead to chondrodysplasias. The gene encoding zebrafish Comp is located on chromosome 11 in synteny with its mammalian orthologs. Zebrafish Comp has a domain structure identical to that of tetrapod COMP and...
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