Article
Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response.
Pharmacogenetics and genomics - 1 Sept 2010
Kiyotani Kazuma, Mushiroda Taisei, Hosono Naoya, Tsunoda Tatsuhiko, Kubo Michiaki, Aki Fuminori, Okazaki Yutaka, Hirata Koichi, Takatsuka Yuichi, Okazaki Minoru, Ohsumi Shozo, Yamakawa Takashi, Sasa Mitsunori, Nakamura Yusuke, Zembutsu Hitoshi
Abstract excerpt
We earlier reported a significant association between the cytochrome P450 2D6 (CYP2D6) genotype and the clinical outcome in 282 Japanese breast cancer patients receiving tamoxifen monotherapy. Although many research groups have provided evidence indicating the CYP2D6 genotype as one of the strongest predictors of tamoxifen response, the results still remain controversial. We hypothesized that concomitant...
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