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Article

A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.

Methods (San Diego, Calif.) - 1 Aug 2010

Anderson Karen S

Abstract excerpt

Nucleoside analogs play an essential role in treating human immunodeficiency virus (HIV) infection since the beginning of the AIDS epidemic and work by inhibition of HIV-1 reverse transcriptase (RT), a viral polymerase essential for DNA replication. Today, over 90% of all regimens for HIV treatment contain at least one nucleoside. Long-term use of nucleoside analogs has been associated with adverse effects...

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Identifiers

PMID: 20573564
DOI: 10.1016/j.ymeth.2010.05.001
PMCID: PMC2916041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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