Article
Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma.
The American journal of pathology - 1 Aug 2010
Bruneau Julie, Canioni Danielle, Renand Amédée, Marafioti Teresa, Paterson Jennifer C, Martin-Garcia Nadine, Gaulard Philippe, Delfau Marie-Hélène, Hermine Olivier, Macintyre Elizabeth, Brousse Nicole, Asnafi Vahid
Abstract excerpt
Angioimmunoblastic T-cell lymphoma (AITL) is the most frequent nodal T-cell lymphoma and is characterized by a polymorphic lymph node infiltrate, various dysimmune disorders, and a poor prognosis. Regulatory T-cells (Treg) play an emerging role in the prognosis of non-Hodgkin B-cell lymphoma and mediate significant autoreactive T-cell suppression. In this report, we demonstrate that numbers of Treg are...
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