Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549.

Journal of experimental & clinical cancer research : CR - 17 Jun 2010

Zhang Wei, Zhu Jing, Bai Jing, Jiang Hui, Liu Fangli, Liu An, Liu Peng, Ji Guohua, Guan Rongwei, Sun Donglin, Ji Wei, Yu Yang, Jin Yan, Meng Xiangning, Fu Songbin

Abstract excerpt

BACKGROUND: The tumor suppressor gene CDKN2A generates at least three different transcriptional variants, each of which is thought to encode a tumor suppressor. However, the inhibitory activities of these variants have not yet been compared in the same cells. Protein therapy is known to have seve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Cell Proliferation

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Flow Cytometry

Share to Immunoenzyme Techniques

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 20565749
DOI: 10.1186/1756-9966-29-74
PMCID: PMC2897778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20565749-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549.PMID 20565749Read ↗

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.Semantic proximity Read ↗

Inhibition of growth of human leukemia cell lines by retrovirally expressed wild-type p16INK4A.Semantic proximity Read ↗

p16INK4A as a human tumor suppressor.Semantic proximity Read ↗

p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1Semantic proximity Read ↗

The tumor-suppressive functions of the human INK4A locus.Semantic proximity Read ↗

Aberrant expression of p16INK4a in human cancers – a new biomarker?Semantic proximity Read ↗

P14ARF: The Absence that Makes the Difference.Semantic proximity Read ↗

Human p16γ, a novel transcriptional variant of p16INK4A, coexpresses with p16INK4A in cancer cells and inhibits cell-cycle progressionSemantic proximity Read ↗

Effect of Ionizing Radiation on the Transcript Variants Expression of p21 Gene.Semantic proximity Read ↗

The role of p16INK4a (Cdkn2a) in mouse plasma cell tumors.Semantic proximity Read ↗

Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent ModificationsSemantic proximity Read ↗

Dual Role of the Alternative Reading Frame ARF Protein in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.