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Article

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.

Cardiovascular research - 1 Nov 2010

Dunlevy Louisa, Bennett Mike, Slender Amy, Lana-Elola Eva, Tybulewicz Victor L, Fisher Elizabeth M C, Mohun Timothy

Abstract excerpt

AIMS: Cardiac malformations are prevalent in trisomies of human chromosome 21 [Down's syndrome (DS)], affecting normal chamber separation in the developing heart. Efforts to understand the aetiology of these defects have been severely hampered by the absence of an accurate mouse model. Such model...

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Share to Chromosomes, Human, Pair 21
Share to Down Syndrome
Share to Fetal Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Atrial

Share to Heart Septal Defects, Ventricular

Share to Imaging, Three-Dimensional

Share to Mice, 129 Strain

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Source

Open in PubMed Open full text

Identifiers

PMID: 20558441
DOI: 10.1093/cvr/cvq193
PMCID: PMC2952533

Genes

DSCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20558441-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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