Article
Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.
American journal of clinical pathology - 1 Jul 2010
Vercauteren Suzanne M, Sung Sandy, Starczynowski Daniel T, Lam Wan L, Bruyere Helene, Horsman Douglas E, Tsang Peter, Leitch Heather, Karsan Aly
Abstract excerpt
The diagnosis of myelodysplastic syndromes (MDSs) relies largely on morphologic and karyotypic abnormalities, present in about 50% of patients with MDS. Array-based genomic platforms have identified copy number alterations in 50% to 70% of bone marrow samples of patients with MDS with a normal karyotype, suggesting a diagnostic role for these platforms. We investigated whether blood granulocytes harbor the same...
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