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Article

The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.

The American journal of psychiatry - 1 Sept 2010

Stevenson Jim, Sonuga-Barke Edmund, McCann Donna, Grimshaw Kate, Parker Karen M, Rose-Zerilli Matthew J, Holloway John W, Warner John O

Abstract excerpt

OBJECTIVE: Food additives can exacerbate ADHD symptoms and cause non-immunoglobulin E-dependent histamine release from circulating basophils. However, children vary in the extent to which their ADHD symptoms are exacerbated by the ingestion of food additives. The authors hypothesized that genetic polymorphisms affecting histamine degradation would explain the diversity of responses to additives. METHOD: In a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20551163
DOI: 10.1176/appi.ajp.2010.09101529

Genes

HNMT
COMT
DRD4

Variants

rs7403703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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