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Article

In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants.

Journal of biomolecular structure & dynamics - 1 Aug 2017

Sang Peng, Hu Wei, Ye Yu-Jia, Li Lin-Hua, Zhang Chao, Xie Yue-Hui, Meng Zhao-Hui

Abstract excerpt

Pyrroline-5-carboxylate reductase (P5CR) encoded by PYCR1 gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor. In this study, we used in silico approaches to examine the role of nonsynonymous single-nucleotide polymorphisms in the PYCR1 gene and their putative functions in the pathogenesis of Cutis Laxa. Among the 348 identified SNPs, 15 were predicted to be...

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Identifiers

PMID: 27677826
DOI: 10.1080/07391102.2016.1222967

Genes

PYCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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