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Article

Mitochondrial damage in the trabecular meshwork of patients with glaucoma.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Jun 2010

Izzotti Alberto, Saccà Sergio C, Longobardi Mariagrazia, Cartiglia Cristina

Abstract excerpt

OBJECTIVES: To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species. METHODS: Mitochondrial damage was evaluated analyzing a common mtDNA...

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Source

Identifiers

PMID: 20547950
DOI: 10.1001/archophthalmol.2010.87

Genes

GSTM1
FAS
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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