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Article

Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue.

Scientific reports - 1 Nov 2024

Vallabh Neeru Amrita, Lane Brian, Simpson David, Fuchs Marc, Choudhary Anshoo, Criddle David, Cheeseman Robert, Willoughby Colin

Abstract excerpt

Glaucoma is a sight threatening neurodegenerative condition of the optic nerve head associated with ageing and marked by the loss of retinal ganglion cells. Mitochondrial dysfunction plays a crucial role in the pathogenesis of neurodegeneration in the most prevalent type of glaucoma: primary open angle glaucoma (POAG). All previous mitochondrial genome sequencing studies in POAG analyzed mitochondrial DNA (mtDNA)...

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Identifiers

PMID: 39487142
DOI: 10.1038/s41598-024-72684-6
PMCID: PMC11530638

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