Article
Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76.
Antimicrobial agents and chemotherapy - 1 Sept 2010
Beshir Khalid, Sutherland Colin J, Merinopoulos Ioannis, Durrani Naeem, Leslie Toby, Rowland Mark, Hallett Rachel L
Abstract excerpt
Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The pfcrt codon 72 to 76 haplotype SVMNT was present in all samples tested, both before and after...
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