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Article

Plasmodium falciparum Isolates Carrying pfk13 Polymorphisms Harbor the SVMNT Allele of pfcrt in Northwestern Indonesia.

Antimicrobial agents and chemotherapy - 22 Jul 2020

Lubis Inke N D, Wijaya Hendri, Lubis Munar, Lubis Chairuddin P, Beshir Khalid B, Sutherland Colin J

Abstract excerpt

Artemisinin-based combination therapy (ACT) is the first-line antimalarial regimen in Indonesia. Susceptibility of Plasmodium falciparum to artemisinin is falling in the Greater Mekong subregion, but it is not known whether the efficacy of current combinations is also threatened in nearby Sumatera. We evaluated the genetic loci pfcrt, pfmdr1, and pfk13, considered to be under selection by artemisinin combination...

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Identifiers

PMID: 32393498
DOI: 10.1128/AAC.02539-19
PMCID: PMC7526839

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