Article
Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives.
Pharmacogenetics - 1 Oct 2001
Runnebaum I B, Wang-Gohrke S, Vesprini D, Kreienberg R, Lynch H, Moslehi R, Ghadirian P, Weber B, Godwin A K, Risch H, Garber J, Lerman C, Olopade O I, Foulkes W D, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin P, Dubé M P, Kieback D G, Narod S A
Abstract excerpt
Oral contraceptives have been shown to be protective against hereditary ovarian cancer. The variant progesterone receptor allele named PROGINS is characterized by an Alu insertion into intron G and two additional mutations in exons 4 and 5. The PROGINS allele codes for a progesterone receptor with increased stability and increased hormone-induced transcriptional activity. We studied the role of the PROGINS allele...
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