Article
Recent advances in the study of candidate genes for adolescent idiopathic scoliosis.
Studies in health technology and informatics - 1 Jan 2010
Fendri K, Patten S, Zaouter C, Parent S, Kaufman G, Labelle H, Edery P, Moldovan F
Abstract excerpt
We used a microarray approach to evaluate gene expression profiles in human AIS osteoblasts, and to identify genes that are differentially expressed following estrogen exposure in non-AIS and AIS human osteoblasts. We found that more than one gene is likely responsible for AIS. Furthermore, some of these genes are estrogen-regulated, suggesting a possible role of estrogens in the etiology of scoliosis.
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