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Article

Long QT syndrome with compound mutations is associated with a more severe phenotype: a Japanese multicenter study.

Heart rhythm - 1 Oct 2010

Itoh Hideki, Shimizu Wataru, Hayashi Kenshi, Yamagata Kenichiro, Sakaguchi Tomoko, Ohno Seiko, Makiyama Takeru, Akao Masaharu, Ai Tomohiko, Noda Takashi, Miyazaki Aya, Miyamoto Yoshihiro, Yamagishi Masakazu, Kamakura Shiro, Horie Minoru

Abstract excerpt

BACKGROUND: Long QT syndrome (LQTS) can be caused by mutations in the cardiac ion channels. Compound mutations occur at a frequency of 4% to 11% among genotyped LQTS cases. OBJECTIVE: The purpose of this study was to determine the clinical characteristics and manner of onset of cardiac events in Japanese patients with LQTS and compound mutations. METHODS: Six hundred three genotyped LQTS patients (310 probands...

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Identifiers

PMID: 20541041
DOI: 10.1016/j.hrthm.2010.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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