Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.

doi:10.1053/j.gastro.2010.06.006

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Article

Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.

Gastroenterology - 1 Sept 2010

Moes Nicolette, Rieux-Laucat Frédéric, Begue Bernadette, Verdier Julien, Neven Bénédicte, Patey Natacha, Torgerson Troy T, Picard Capucine, Stolzenberg Marie-Claude, Ruemmele Corinne, Rings Edmond Hhm, Casanova Jean-Laurent, Piloquet Hugues, Biver Armand, Breton Anne, Ochs Hans D, Hermine Olivier, Fischer Alain, Goulet Olivier, Cerf-Bensussan Nadine, Ruemmele Frank M

Abstract excerpt

BACKGROUND & AIMS: Little is known about the pathophysiology of early onset forms of autoimmune enteropathy (AIE). AIE has been associated with mutations in FOXP3-a transcription factor that controls regulatory T-cell development and function. We analyzed the molecular basis of neonatal or early postnatal AIE using clinical, genetic, and functional immunological studies. METHODS: Gastroenterological and...

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PMID: 20537998
DOI: 10.1053/j.gastro.2010.06.006

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FOXP3

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