Article
Nuclear Factor (NF) kappaB polymorphism is associated with heart function in patients with heart failure.
BMC medical genetics - 9 Jun 2010
Santos Diogo G B, Resende Marina F, Mill José G, Mansur Alfredo J, Krieger José E, Pereira Alexandre C
Abstract excerpt
BACKGROUND: Cardiac remodeling is generally an adverse sign and is associated with heart failure (HF) progression. NFkB, an important transcription factor involved in many cell survival pathways, has been implicated in the remodeling process, but its role in the heart is still controversial. Recently, a promoter polymorphism associated with a lesser activation of the NFKB1 gene was also associated with Dilated...
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