Article
Phenotypic commitment of monocytes towards a protective hemoglobin scavenging phenotype (CD14(pos)CD163(high)HLA-DR(low))following cardiopulmonary bypass.
Cytometry. Part B, Clinical cytometry - 1 Sept 2010
Quimby Kim R, Greenidge Andre, Harris Anthony, Landis R Clive
Abstract excerpt
BACKGROUND: Intravascular hemolysis may cause tissue injury directly or via a systemic inflammatory response. Under physiological conditions, extracorpuscular hemoglobin (Hb) is bound by haptoglobin(Hp) and the complex internalized via the hemoglobin scavenger receptor CD163 on monocytes, prior to catabolism via heme-oxygenase-1 (HO-1). Recently, a novel subset of CD68(pos)CD163(high)HLA-DR(low) macrophages with...
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