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Article

Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF.

Journal of translational medicine - 25 May 2018

Laudanski Krzysztof, Zawadka Mateusz, Polosak Jacek, Modi Jaymin, DiMeglio Matthew, Gutsche Jacob, Szeto Wilson Y, Puzianowska-Kuznicka Monika

Abstract excerpt

BACKGROUND: It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclear how persistent is the macrophage-like characteristics in circulating monocytes (MO). In this study, 20 patients who underwent non-emergent cardiopulmonary bypass had their monocytes...

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Source

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Identifiers

PMID: 29801457
DOI: 10.1186/s12967-018-1518-3
PMCID: PMC5970449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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