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Article

SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data.

Nucleic acids research - 1 Oct 2011

Wei Zhi, Wang Wei, Hu Pingzhao, Lyon Gholson J, Hakonarson Hakon

Abstract excerpt

We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled or individual next-generation sequencing (NGS) data. We formulate variant calling as a hypothesis testing problem and employ a binomial-binomial model to test the significance of observed allele frequency against sequencing error. SNVer reports one single overall P-value for evaluating the significance of a candidate...

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Identifiers

PMID: 21813454
DOI: 10.1093/nar/gkr599
PMCID: PMC3201884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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