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Article

Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.

Pharmaceutical research - 1 Mar 1991

Coupe A J, Davis S S, Wilding I R

Abstract excerpt

The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male volunteers after repeated weekly administration. The dosage forms were labeled with gamma-emitting radionuclides and the transit of the formulations was monitored on 4 separate study days using the technique of dual-isotope gamma scintigraphy. Gastric...

Topics

Adult
Chemistry, Pharmaceutical
Dosage Forms
Drug Implants
Gastrointestinal Transit
Genetic Variation
Humans
Indium Radioisotopes
Male
Pharmacokinetics
Scintillation Counting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tablets

Source

Identifiers

PMID: 2052525
DOI: 10.1023/a:1015849700421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2052525-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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