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Article

Are "functionally related polymorphisms" of renin-angiotensin-aldosterone system gene polymorphisms associated with hypertension?

BMC cardiovascular disorders - 2 Jun 2010

Hahntow Ines N, Mairuhu Gideon, van Valkengoed Irene Gm, Koopmans Richard P, Michel Martin C

Abstract excerpt

BACKGROUND: Genotype-phenotype association studies are typically based upon polymorphisms or haplotypes comprised of multiple polymorphisms within a single gene. It has been proposed that combinations of polymorphisms in distinct genes, which functionally impact the same phenotype, may have stronger phenotype associations than those within a single gene. We have tested this hypothesis using genes encoding...

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Identifiers

PMID: 20525211
DOI: 10.1186/1471-2261-10-23
PMCID: PMC2892429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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