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Article

Mutation and association analysis of GEN1 in breast cancer susceptibility.

Breast cancer research and treatment - 1 Nov 2010

Turnbull Clare, Hines Sarah, Renwick Anthony, Hughes Deborah, Pernet David, Elliott Anna, Seal Sheila, Warren-Perry Margaret, Gareth Evans D, Eccles Diana, Stratton Michael R, Rahman Nazneen

Abstract excerpt

GEN1 was recently identified as a key Holliday junction resolvase involved in homologous recombination. Somatic truncating GEN1 mutations have been reported in two breast cancers. Together these data led to the proposition that GEN1 is a breast cancer predisposition gene. In this article we have formally investigated this hypothesis. We performed full-gene mutational analysis of GEN1 in 176 BRCA1/2-negative...

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Source

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Identifiers

PMID: 20512659
DOI: 10.1007/s10549-010-0949-1
PMCID: PMC3632835

Genes

GEN1
BRCA1
ATM
BRCA2
BRIP1
CHEK2
FGFR2
PALB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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