Article
[Genetic factors associated with age-related macular degeneration].
Medecine sciences : M/S - 1 May 2010
Leveziel Nicolas, Puche Nathalie, Zerbib Jennyfer, Benlian Pascale, Coscas Gabriel, Soubrane Gisèle, Souied Eric
Abstract excerpt
Age related macular degeneration (AMD) is the leading cause of vision loss in the elderly in developed countries. Genetic factors play a major role in this multifactorial and polygenic disease. Genomewide analysis identified two loci on 1q25-31 and 10q26 chromosomes associated with AMD, and association studies highlighted the implication of SNPs located in the complement H factor gene (CFH) on 1q25-31 and in...
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