Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survivin is regulated by interleukin‐4 in colon cancer stem cells

20 May 2010

Abstract excerpt

Colorectal cancer has provided an important model to test the stem cell hypothesis of cancer origin, which implies that cancer arises as a result of genetic aberrations in stem cells leading to deregulation of the proliferation/differentiation balance. We and others have demonstrated that, similarly to other solid tumors, colon carcinogenesis and progression are dictated by highly apoptosis-resistant stem-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell death mechanisms and regulation
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20506498
DOI: 10.1002/jcp.22238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survivin is regulated by interleukin‐4 in colon cancer stem cellsPMID 20506498Read ↗

IL-4-mediated drug resistance in colon cancer stem cellsSemantic proximity Read ↗

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cellsSemantic proximity Read ↗

STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)Semantic proximity Read ↗

Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progressionSemantic proximity Read ↗

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer—A Promising Signaling Network for Therapeutic InterventionsSemantic proximity Read ↗

CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5Semantic proximity Read ↗

Improvement of 5-Fluorouracil Chemosensitivty In Colorectal Cancer Cells by siRNA-Mediated Silencing of STAT6 OncogeneSemantic proximity Read ↗

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancerSemantic proximity Read ↗

Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cellsSemantic proximity Read ↗

Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.Semantic proximity Read ↗

Assessment of the Influence of 5-fluorouracil on the SMAD4 Gene Expression, Apoptosis induction and DNA Damage in the Human CACO-2 Cell LineSemantic proximity Read ↗

Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.