Article
Toll-like receptor 4 promoter polymorphisms: common TLR4 variants may protect against severe urinary tract infection.
PloS one - 20 May 2010
Ragnarsdóttir Bryndís, Jönsson Klas, Urbano Alexander, Grönberg-Hernandez Jenny, Lutay Nataliya, Tammi Martti, Gustafsson Mattias, Lundstedt Ann-Charlotte, Leijonhufvud Irene, Karpman Diana, Wullt Björn, Truedsson Lennart, Jodal Ulf, Andersson Björn, Svanborg Catharina
Abstract excerpt
BACKGROUND: Polymorphisms affecting Toll-like receptor (TLR) structure appear to be rare, as would be expected due to their essential coordinator role in innate immunity. Here, we assess variation in TLR4 expression, rather than structure, as a mechanism to diversify innate immune responses. METHODOLOGY/PRINCIPAL FINDINGS: We sequenced the TLR4 promoter (4,3 kb) in Swedish blood donors. Since TLR4 plays a vital...
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