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Article

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants.

Nature communications - 2 May 2018

Nagata Ryuhei, Fujihashi Masahiro, Sato Takaaki, Atomi Haruyuki, Miki Kunio

Abstract excerpt

Almost all kinases utilize ATP as their phosphate donor, while a few kinases utilize pyrophosphate (PPi) instead. PPi-dependent kinases are often homologous to their ATP-dependent counterparts, but determinants of their different donor specificities remain unclear. We identify a PPi-dependent member of the ribokinase family, which differs from known PPi-dependent kinases, and elucidate its PPi-binding mode based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29720581
DOI: 10.1038/s41467-018-04201-z
PMCID: PMC5931981

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