Article
Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City.
The American journal of clinical nutrition - 1 Jul 2010
Pilsner J Richard, Hu Howard, Wright Robert O, Kordas Katarzyna, Ettinger Adrienne S, Sánchez Brisa N, Cantonwine David, Lazarus Alicia L, Cantoral Alejandra, Schnaas Lourdes, Téllez-Rojo Martha Maria, Hernández-Avila Mauricio
Abstract excerpt
BACKGROUND: Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations. OBJECTIVE: The objective of this study was to examine potential...
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