Article
Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity.
Development (Cambridge, England) - 1 Jul 2010
Inaki Mikiko, Shinza-Kameda Makiko, Ismat Afshan, Frasch Manfred, Nose Akinao
Abstract excerpt
Little is known about the genetic program that generates synaptic specificity. Here we show that a putative transcription factor, Teyrha-Meyhra (Tey), controls target specificity, in part by repressing the expression of a repulsive cue, Toll. We focused on two neighboring muscles, M12 and M13, which are innervated by distinct motoneurons in Drosophila. We found that Toll, which encodes a transmembrane protein...
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